1. Skip to Menu
  2. Skip to Content
  3. Skip to Footer

Books

Available from ClinLab Navigator: Essentials of Transfusion Medicine, a convenient and comp...

Books
  • Books

    Books

  • Brand NEW APP - Lab Test Navigator: 800+ Lab Tests for iPhone

    Brand NEW APP - Lab Test Navigator: 800+ Lab Tests for iPhone

  • Brand NEW App - Lab Test Navigator: 800+ Lab Tests for iPad

    Brand NEW App - Lab Test Navigator: 800+ Lab Tests for iPad

Previous
Next

ALK Gene Mutation

Approximately 3 to 5% of non-small cell lung carcinomas (NSCLC) have a rearrangement of the ALK (Anaplastic Lymphoma Kinase) gene, resulting in fusion between ALK and another gene, ALK activation, impaired apoptosis, and abnormal cell proliferation. Tumors expressing ALK fusions are likely to respond to ALK kinase inhibitor drugs such as XALKORI® (crizotinib).

The National Comprehensive Cancer Network (NCCN) guidelines recommend ALK testing for patients with recurrent or metastatic NSCLC with histological subtypes of adenocarcinoma, large cell carcinoma, or NSCLC NOS (not otherwise specified), and for squamous cell carcinoma in never-smokers or when biopsy specimens are small.

FISH is preferred over molecular testing for ALK testing because it detects all known gene rearrangements. The ALK gene has more than 20 known rearrangement partner genes. The most common EML4-ALK fusion has at least 15 variants. Vysis ALK Break Apart FISH Probe Kit is an FDA approved companion diagnostic tests to identify patients for this therapy

In addition to the proven role it plays in select lung cancers, ALK has been found to have a pathogenic role in many cancers including diffuse large B-cell lymphoma, inflammatory myofibroblastic tumor, esophageal squamous cell carcinoma, colorectal cancer and breast cancer. It is estimated that more than 250,000 new cancer diagnoses in the United States each year can be linked to ALK mutations and fusions.

Updated Articles

Legionella Tests

Legionella pneumophila is a waterborne bacterium responsible for Legionnaires’ disease, which is a severe form of pneumonia that occurs most often in susceptible persons. Cigarette smoking, chronic lung disease and immunosuppression are risk factors…

New Articles

Babesia microti

Babesiosis is an emerging zoonotic disease caused primarily by Babesia microti, an intraerythocytic protozoan. Babesia microti is endemic to the northeastern and upper midwestern United States where it is usually transmitted by the blacklegged tick,…

Blog

Endocrine Causes of…

This year, The Endocrine Society issued a scientific statement on screening for endocrine causes of hypertension. It includes recommendations for laboratory testing for each of the different forms of endocrine hypertension including: Primary…

Stay Informed

Amazon Book

Our Sponsors

Login Form

Lectures

Cases That Kept Me Up At Night: Case #1

Case #1 is an overview of transfusion reactions and a discussion of a neonate with both NAIT and Rh HDN.

View More Lectures

Mobile Applications

iPad mini Horz Vert 300w

Get it for: iPhoneiPad

ClinLab Navigator Information

McAfee SECURE sites help keep you safe from identity theft, credit card fraud, spyware, spam, viruses and online scams
© 2015 ClinLab Navigator, LLC.