1. Skip to Menu
  2. Skip to Content
  3. Skip to Footer

Books

Available from ClinLab Navigator: Essentials of Transfusion Medicine, a convenient and comp...

Books
  • Books

    Books

  • Brand NEW APP - Lab Test Navigator: 800+ Lab Tests for iPhone

    Brand NEW APP - Lab Test Navigator: 800+ Lab Tests for iPhone

  • Brand NEW App - Lab Test Navigator: 800+ Lab Tests for iPad

    Brand NEW App - Lab Test Navigator: 800+ Lab Tests for iPad

Previous
Next

Carbohydrate Deficient Transferrin

Normal transferrin molecules contain 4 sialic acid residues. Chronic alcohol consumption causes a decrease in sialylation, leading to increased quantities of disialo- and asialotransferrin. Carbohydrate deficient transferrin (CDT) is used as a serum biomarker for chronic alcohol abuse. CDT typically normalizes within several weeks of abstinence of alcohol use.

It is important to remember that congenital disorders of glycosylation can also produce CDT. However, alcohol consumption increases the relative amount of monoglycosylated transferrin more than is seen in congenital disorders of glycosylation. Other conditions such as hereditary fructose intolerance, galactosemia, and liver disease may result in increased levels of CDT. Bacterial contamination of the specimen may also cause falsely elevated CDT values.

CDT testing alone is not recommended for general screening for alcoholism. CDT testing should be combined with gamma glutamyltransferase, mean corpuscular volume and ethylglucuronide analysis. clinicians can expect to identify the majority of patients who consume a large amount of alcohol.

Transferrin is purified by affinity chromatography and the relative quantity of carbohydrate deficient transferrin is detected by mass spectrometry. Normal level of CDT is <0.10.

Specimen requirement is a red top tube of blood.

Updated Articles

BK Virus…

BK is a type of polyomavirus that is ubiquitous in nature and infects most people in early childhood. Seroprevalence is 60-100% in epidemiologic studies. Following primary infection, the virus becomes latent in lymphocytes and renal epithelium.…

New Articles

Babesia microti

Babesiosis is an emerging zoonotic disease caused primarily by Babesia microti, an intraerythocytic protozoan. Babesia microti is endemic to the northeastern and upper midwestern United States where it is usually transmitted by the blacklegged tick,…

Blog

Tickborne Infectious…

Tickborne diseases are increasing in the United States, and the geographic range of tick vectors is expanding. Tickborne diseases are challenging to diagnose, because they present with vague symptoms such as fever, constitutional symptoms, and…

Stay Informed

Amazon Book

Our Sponsors

Login Form

Lectures

Cases That Kept Me Up At Night: Case #1

Case #1 is an overview of transfusion reactions and a discussion of a neonate with both NAIT and Rh HDN.

View More Lectures

Mobile Applications

iPad mini Horz Vert 300w

Get it for: iPhoneiPad

ClinLab Navigator Information

McAfee SECURE sites help keep you safe from identity theft, credit card fraud, spyware, spam, viruses and online scams
© 2015 ClinLab Navigator, LLC.