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Pregabalin

Pregabalin (Lyrica) is an anticonvulsant drug used to treat partial seizures. Pregabalin is also commonly prescribed to treat neuropathic pain and fibromyalgia. Measurement of the concentration of Pregabalin in serum is helpful in assessing compliance and monitoring patients with renal failure who generally require lower dosages.

Therapeutic concentration is 2 to 5 ug/mL when measured by liquid chromatography plus mass spectrometry. Toxicity may occur at serum concentrations greater than 10 ug/mL. Specimen requirement is a red top tube of blood.

Hiemke, C, Baumann P, Bergemann N, et al: AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011. Pharmacopsychiatry 2011;44:195-235

Updated Articles

Platelet…

Platelet transfusion refractoriness (PTR) is defined as the occurrence of at least two poor incremental platelet counts after transfusion of a standard dose of platelet s. PTR is classified as either immune or nonimmune. Immune-mediated PTR is…

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Factor VIII…

Factor VIII is a large glycoprotein cofactor with a molecular weight of 320 kilodaltons that is synthesized mainly in hepatocytes, but also in hepatic macrophages, megakaryocytes, and endothelial cells. Factor VIII circulates in plasma bound to von…

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Hematology Hashtag…

Twitter is becoming an increasingly valuable tool for discovery of fascinating case studies, communicating with colleagues and keeping abreast of the most recent advancements in all subspecialties of Pathology. In March 2017, ClinLabNavigator…

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Cases That Kept Me Up At Night: Case #1

Case #1 is an overview of transfusion reactions and a discussion of a neonate with both NAIT and Rh HDN.

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