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Pregabalin

Pregabalin (Lyrica) is an anticonvulsant drug used to treat partial seizures. Pregabalin is also commonly prescribed to treat neuropathic pain and fibromyalgia. Measurement of the concentration of Pregabalin in serum is helpful in assessing compliance and monitoring patients with renal failure who generally require lower dosages.

Therapeutic concentration is 2 to 5 ug/mL when measured by liquid chromatography plus mass spectrometry. Toxicity may occur at serum concentrations greater than 10 ug/mL. Specimen requirement is a red top tube of blood.

Hiemke, C, Baumann P, Bergemann N, et al: AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011. Pharmacopsychiatry 2011;44:195-235

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Thiamine

Thiamine (Vitamin B1) deficiency causes Wernicke's encephalopathy, which is characterized by the classic triad of mental confusion, oculomotor dysfunction, and gait ataxia. Punctate hemorrhages around the third and fourth ventricles are…

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Thiamine

Thiamine (Vitamin B1) deficiency causes Wernicke's encephalopathy, which is characterized by the classic triad of mental confusion, oculomotor dysfunction, and gait ataxia. Punctate hemorrhages around the third and fourth ventricles are…

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Metabolic Syndrome

The metabolic syndrome is defined as the co-occurrence of metabolic risk factors for both type 2 diabetes and cardiovascular disease. These risk factors include abdominal obesity, hyperglycemia, dyslipidemia, and hypertension. All of them are…

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Lectures

Cases That Kept Me Up At Night: Case #1

Case #1 is an overview of transfusion reactions and a discussion of a neonate with both NAIT and Rh HDN.

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