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The question and answer section is a repository of user generated questions regarding material posted on this web site. We encourage visitors to submit questions and we will attempt to provide prompt responses via e-mail and this Q & A database. Sharing ideas will allow all of us to navigate our laboratories through calmer seas.



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Blood Bank (6)Chemistry (13)Flow Cytometry (0)
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Urinalysis (1)Transfusion (1) 
 
Top 5 Articles
What is the normal range for early morning creatinine to cortisol ratio? I am intending to use it as a screening tool for hypercortism and can only seen to find ref ranges for animals!
You ask what is the normal range for early morning creatinine to cortisol ratio. It is not clear if you are planning to measure cortisol in plasma or urine. I am ......
●●● Last Update: 2007-11-02 Views: 13
A patient with an RH weakly positive begin transfusion with RH positive blood unit. The transfusion was discontinued because later the Medical Technologist check that the protocol recommend that recipient Du positive ( weakly positive Rh) needs to be transfused with blood RH negative. The protocol said that a weakly positive RH person shoul d be considered as RH negative recipient and as RH positive donor. The patient is fine. No change in his test before and after the transfufion. Should this even be consdered a Sentinel event that has to be reported to the JCHA ect.?
Historically, if a patient typed as Rh negative, additional testing was then performed to determine if they had Rh Du or weak D expression. In the past several years, weak D ......
Not Rated Last Update: 2007-11-02 Views: 10
I read that 25% of raynaud's phenomenom patients have centromere antibodies. Does this mean that these patients are at risk for scleroderma or just that centromere antibodies are associated with raynaud's by itself?
Raynaud phenomenon is diagnosed either by physical examination or by eliciting a specific clinical history. An ANA test does not help establish the diagnosis, but may provide prognostic information. Raynaud phenomenon ......
Not Rated Last Update: 2007-11-02 Views: 10
What are the hematologic manifestations of congenital infections? e.g. CMV, toxoplasmosis. We have a 3 month old patient with myocarditis, microcephaly, rash and hemolytic anemia. Toxic changes and thrombocytosis seen on smear... Is this consistent with a dx of congenital CMV or congenital Toxoplasmosis? And if untreated, what is the course of these hematologic changes? When do they return to normal?
Laboratory findings in congenital toxoplasmosis include leukocytosis, predominately due to an increase in lymphocytes and reactive lymphocytes. The most common hematologic complication is hemolytic anemia.   The most common hematologic findings ......
●● Last Update: 2007-11-02 Views: 7
Dear staff, I have learned the following from your website: 1- ristocetin cofactor: platelet from healthy donor + plasma from patient + ristocetin 2- ristocetin induced platelet aggregation: platelet from patient + plasma from patient + ristocetin 3- ristocetin cofactor is more sensitive and specific than RIPA I ask: a- what is the difference between two exams after all? b- why ristocetin cofactor is more sensitive and specific than RIPA?
R CoF tests only the patient\'s plasma (VWF activity) against fixed platelets whereas RIPA tests patient\'s plasma and platelets. That would account for greater specificity. I\'m not sure of the reason ......
Not Rated Last Update: 2007-12-02 Views: 5
Last 5 Articles
I work in a laboratory, however I am not a Med Tech. I am concerned about the number of patients in an outpatient setting getting misdiagnosed in regards to a UTI. I have had 2 doctors tell me that if a urine dipstick is negative, the microscopic will be negative also. I asked 2 separate med techs this question (these people do macro/micro UA's their entire shift) and they said that is absolutely false. A urine dipstick test will only be positive if you have a nitrate producing bacteria in your urine. There are other bacteria's that are not nitrate producing, therefore creating a negative dipstick test. They both said that in their experience, which is 15-20 years of looking at urines, they consistently have urines that are negative on dipstick, but have high quantity of bacteria in them. I asked are these cath urines, clean catch urines, etc, and they said yes, any type. The majority of their testing is from a fresh sample, such as inpatient or emergency room. My question is, where are you getting your information from?
Urine dipsticks are relatively insensitive for detecting urinary tract infections. I actually prefer the leukocyte esterase over the nitrate test for detecting UTI, but both can be falsely negative. The information ......
Not Rated Last Update: 2008-04-17 Views: 1
I would like some references on the information published here about Platelet transfusion, specifically about the ABO-nonidentical platelets. In several places, it appears nonidentical is not consistently used. A product may be "nonidentical" but compatible. Under the section: Platelet ABO Compatibility, the 2nd and 3rd paragraph are specifically the information are I would like referenced.
See the attached Word document for all references....
Not Rated Last Update: 2008-02-28 Views: 3
I live in Canada, and our labs use different measurements. Specifically I am interested in the Serum Calcium and Parathyroid Hormone values.....can you tell me how to convert our pmol/L to pg/ml for PTH and the mmol/L to your mg/dl for Calcium.
The conversion factor for converting Calcium from mg/dL to mmol/L is 0.2495. The conversion factor for converting intact PTH from pmol/L to ng/L is 9.424.  ...
Not Rated Last Update: 2008-02-26 Views: 5
What are the goals/objectives of a clinical lab? What are the various sub depatments of a clinical lab and the personnel working in the lab?
Pathology is the study of disease and is the broadest of the medical specialties. Pathology has 2 main divisions; anatomic and clinical pathology. Clinical pathology encompasses the clinical laboratory and ......
Not Rated Last Update: 2008-01-28 Views: 1
Hello, I am looking for plastic blood collection tube with ACD solutionB. But I can find only glass tubes, could you tell me why?
I also could not find a plastic tube with ACD solution B. I do not know why this tube is only available in glass....
Not Rated Last Update: 2008-01-26 Views: 1