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Vitamin E

Vitamin E is a tocopherol that functions as an antioxidant, protecting the integrity of lipid membranes and preventing oxidative damage to retinol. Vitamin E deficiency can be caused by conditions that cause fat malabsorption such as cholestatic liver disease, pancreatic insufficiency and small intestinal resection or disease. Deficiency of Vitamin E in adults and children causes reversible neuropathy and hemolysis..

Specimen requirement is a red top tube of blood.  Patient should be fasting overnight to prevent falsely elevated concentrations.  Vitamin E is measured in serum by liquid chromatography combined with tandem mass spectrometry.

Vitamin E levels below 5.0 ug/mL are considered deficient. Levels greater than 40 mg/L indicate excessive vitamin E. 

Updated Articles

Platelet…

Platelet transfusion refractoriness (PTR) is defined as the occurrence of at least two poor incremental platelet counts after transfusion of a standard dose of platelet s. PTR is classified as either immune or nonimmune. Immune-mediated PTR is…

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Factor VIII…

Factor VIII is a large glycoprotein cofactor with a molecular weight of 320 kilodaltons that is synthesized mainly in hepatocytes, but also in hepatic macrophages, megakaryocytes, and endothelial cells. Factor VIII circulates in plasma bound to von…

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Hematology Hashtag…

Twitter is becoming an increasingly valuable tool for discovery of fascinating case studies, communicating with colleagues and keeping abreast of the most recent advancements in all subspecialties of Pathology. In March 2017, ClinLabNavigator…

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Lectures

Cases That Kept Me Up At Night: Case #1

Case #1 is an overview of transfusion reactions and a discussion of a neonate with both NAIT and Rh HDN.

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